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CD40, cancer, therapy, PI3 kinase, immunotherapy, gene therapy, signaling, European Commission Program, FP6, Virtual Medical Lab, Faculty of Medicine, University of Crete
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Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Genin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, Andre F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors. Nature Medicine 15: 1170-8, 2009.
Wagner EF and Nebreda AR Signal integration by JNK and p38 MAPK pathways in cancer development. Nature Reviews in Cancer 9: 537-549, 2009
Loskog AS and Eliopoulos AG The Janus faces of CD40 in Cancer. Seminars in Immunology 21: 301-7, 2009
Mistrik M, Oplustilova L, Lukas J, Bartek J Low-dose DNA damage and replication stress responses quantified by optimized automated single-cell imagine analysis.. Cell cycle 8: 2592-2599, 2009
Batsi C, Markopoulou S, Varholomathos G, Georgiou I, Kanavaros P, Gorgoulis VG, Marcu KB, Kolettas E Chronic NK-kappaB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response. Mechanisms of Ageing and Development 130: 409-419, 2009
Terme M, Mignot G, Ullrich E, Bonmort M, Minard-Colin V, Jacquet A, Schultze JL, Kroemer G, Leclerc C, Chaput N, Zitvogel L The dendritic cell-like functions of IFN-producing killer dendritic cells reside in the CD11b+ subset and are licensed by tumor cells. Cancer Research 69:6590-7, 2009
Pateras IS, Apostolopoulou K, Niforou K, Kotsinas A, Gorgoulis VG: p57KIP2: "Kip-ing the cell under control. Molecular Cancer Research 7: 1902-19, 2009
Buganim Y, Solomon H, Rais Y, Kistner D, Nachmany I, Beatus T, Brait M, Madar S, Goldstein I, Kalo E, Adam N, Yaskavich M, Rivlin N, Kogan I, Brosh E, Sefadia-Elad G, Goldfinger N, Sidransky N, Kloog Y, Rotter V p53 regulates the Ras circuit to inhibit the expression of a cancer-related gene signature by various molecular pathways. Cancer Research 70: 2274-2284, 2010.
Blazkova H, Krejcikova K, Moudry P, Frisan T, Hodny Z, Bartek J Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signaling. Journal of Cellular and Molecular Medicine 14: 357-367, 2010.
Chakraborty JB, Mann DA NF-kappaB signalling: Embracing complexity to achieve transition. Journal of Hepatology 52:285-291, 2010.
Addadi, Y, Moskovits N, Granot D, Lozano G, Carmi Y, Apte RN, Neeman, M and Oren M p53 Status in Stromal Fibroblasts Modulates Tumor Growth in an SDF1-Dependent Manner. Cancer Res 70: 9650-9658, 2010.
Bartek J, Mistrik M, and Bartkova J Long-distance inflammatory and genotoxic impact of cancer in vivo. PNAS 107: 17861–17862, 2010
Bartkova J, Hamerlik P, Stockhausen MT, Ehrmann J, Hlobilkova A, Laursen H, Kalita O, Kolar Z, Poulsen HS, Broholm H, Lukas J and Bartek J Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas. Oncogene  29: 5095–5102, 2010
Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der Gulden H, Hiddingh S, Thanasoula M, Kulkarni A, Yang Q, Haffty BG, Tommiska J, Blomqvist C, Drapkin R, Adams DJ, Nevanlinna H, Bartek J, Tarsounas M, Ganesan S & Jonkers J. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nature Struct Mol Biol. 17: 688-95, 2010
Buonocore S, Ahern PP, Uhlig HH, Ivanov II, Littman DR, Maloy KJ & Powrie F. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464: 1371-5, 2010
Cohen I, Rider P, Carmi Y, Braiman A, Dotan S, White MR, Voronov E, Martin MU, Dinarello CA, and Apte RN Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation. PNAS 107: 2574–2579, 2010
Cuadrado A and Nebreda AR Mechanisms and functions of p38 MAPK signalling Biochem. J.  429: 403–417, 2010
Cuadrado A, Corrado N, Perdiguero E, Lafarga V, Munoz-Canoves P and Nebreda AR. Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation  EMBO J 29: 2014–2025, 2010
Mitchell K, Svenson KB, Longmate WM, Gkirtzimanaki K, Sadej R, Wang X, Zhao J, Eliopoulos AG, Berditchevski F, and Dipersio CM. Suppression of Integrin α3β1 in Breast Cancer Cells Reduces Cyclooxygenase-2 Gene Expression and Inhibits Tumorigenesis, Invasion, and Cross-Talk to Endothelial Cells Cancer Research 70:6359-67, 2010
Schramek D, Leibbrandt A, Sigl V, Kenner L, Pospisilik JA, Lee HJ, Hanada R, Joshi PA, Aliprantis A, Glimcher L, Pasparakis M, Khokha R, Ormandy CJ, Widschwendter M, Schett G, Penninger JM. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer Nature  468: 98-102, 2010
Gorgoulis VG, Halazonetis TD . Oncogene-induced senescence: the bright and dark side of the response. Curr Opin Cell Biol , 22: 816-27 2010
Hubackova S, Novakova Z, Krejcikova K, Kosar M, Dobrovolna J, Hanzlikova H, Vancurova M, Barath P, Bartek J, Hodny Z . Regulation of the PML tumour suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling. Cell Cycle , 9: 3085-99 2010
Liontos A, Velimezi G, Pateras IS, Angelopoulou R, Papavassiliou AG, Bartek J, Gorgoulis VG The roles of p27(Kip1)and DNA damage signaling in the chemotherapy-induced delayed cell cycle checkpoint. J. Cell Mol. Med. , Epub ahead of print 2010
Kotsinas A, Pateras IS, GalanosPS, Karamouzis MV, Sfikakis PP, Gorgoulis, VG. Why is the p53-inducible gene 3 rarely affected in cancer? Oncogene , 29: 5520 2010
Ma Y, Kepp O, Ghiringhelli F, Apetoh L, Aymeric L, Locher C, Tesniere A, Martins I, Ly A, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L   Chemotherapy and Radiotherapy: cryptic anticancer vaccines. Semin Immunol , 22: 113-24 2010
Sigala F, Savvari P, Liontos M, Sigalas P, Pateras IS, Papalampros A, Basdra EK, Kolettas E, Kotsinas A, Papavassiliou AG, Gorgoulis VG . Increased expression of bFGF is associated with carotid atherosclerotic plaques instability engaging the NF-kappaB pathway. J Cell Mol Med , Epub ahead of print 2010
Zitvogel L, Kepp O, Aymeric L, Ma Y, Locher C, Delahaye NF, Andre F, Kroemer G . Integration of host-related signatures with cancer cell-derived predictors for the optimal management of anti-cancer chemotherapy. Cancer Res. , 70: 9538-43 2010
Wimmer R, Baccarini M. Partner exchange: protein-protein interactions in the raf pathway. Trends Biochem Sci.  35: 660-8, 2010
Aylon Y, Oren, M New plays in the p53 theatre Curr. Op. Gen. Dev. 21: 86-92, 2011
Ma Y, Conforti R, Aymeric L, Locher C, Kepp O, Kroemer G, Zitvogel, L How to improve the immunogenicity of chemotherapy and radiotherapy Cancer Metastasis Reviews , 30: 71-82 2011
Ma Y, Aymeric L, Locher C, Kroemer G, Zitvogel L The dendritic cell-tumour cross-talk in cancer. Curr Opin Immunol , 23: 146-52 2011
Viaud S, Flament C, Zoubir M, Pautier P, Lecesne A, Ribrag V, Soria JC, Marty V, Viehl P, Robert C, Chaput N, Zitvogel L Cyclophosphamide Induces Differentiation of Th17 cells in cancer patients. Cancer Res.  71: 661-665, 2011
Vivier E, Raulet DH, Moretta A, Caliguri MA, Zitvogel L, Lanier LL, Yokoyama WM, Ugolini S. Innate or adaptive immunity? The example of natural killer cells. Science , 7: 44-49, 2011
Zoubir M, Flament C, Gdoura A, Bahleda R, Litinova E, Soumelis V, Conforti R, Viaud S, Soria JC, Kroemer G, Zitvogel L, Chaput N An inhibitor of cyclin-dependent kinases suppresses TLR signaling and increases the susceptibility of cancer patients to herpes viridae. Cell Cycle  1: 118-26 2011
Kosar M, Bartkova J, Hubackova S, Hodny Z, Lukas J Bartek J. Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner, and follow expression of p16ink4a Cell Cycle 10:457-468, 2011
Delahaye NF, Rusakiewicz S, Martins I, Ménard C, Roux S, Lyonnet L, Paul P, Sarabi M, Chaput N, Semeraro M, Minard-Colin V, Poirier-Colame V, Chaba K, Flament C, Baud V, Authier H, Kerdine-Römer S, Pallardy M, Cremer I, Peaudecerf L, Rocha B, Valteau-Couanet D, Gutierrez JC, Nunès JA, Commo F, Bonvalot S, Ibrahim N, Terrier P, Opolon P, Bottino C, Moretta A, Tavernier J, Rihet P, Coindre JM, Blay JY, Isambert N, Emile JF, Vivier E, Lecesne A, Kroemer G, Zitvogel L Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nature Medicine 2011
Carmi Y, Rinott G, Dotan S, Elkabets M, Rider P, Voronov E, Apte RN Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis J Immunol. , 186:3462-71, 2011.
Ma, Y, L Aymeric, C Locher, SR Mattarollo, NF Delahaye, P Pereira, L Boucontet, L Apetoh, F Ghiringhelli, N Casares, JJ Lasarte, G Matsuzaki, K Ikuta, B Ryffel, K Benlagha, A Tesniere, N Ibrahim, J Dechanet-Merville, N Chaput, MJ Smyth, G Kroemer, and Zitvogel L Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J Exp Med , 208:491-503, 2011.
Papanikolaou N, Pafilis E, Nikolaou S, Ouzounis CA, Iliopoulos I, Promponas VJ . BioTextQuest: a web-based biomedical text mining suite for concept discovery Bioinformatics , 2011 Dec1; 27(23):3327-8
Ebrahimkhani MR, Oakley F, Murphy LB, Mann J, Moles A, Perugorria MJ, Ellis E, Lakey AF, Burt AD, Douglass A, Wright MC, White SA, Jaffre F, Moroteaux L, Mann DA Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease Nat Med, 2011 17(12):1668-73
Gaspar-Pereira S, Fullard N, Townsend PA, Banks PS, Ellis EL, Fox C, Maxwell AG, Murphy LB, Kirk A, Baurer R, Caamano JH, Figg N, Foo RS, Mann J, Mann DA Oakley F. The NF-kB subunit c-Rel stimulates cardiac hypertrophy and fibrosis Am J Pathol, 2011
Maloy KJ, Powrie F . Intestinal homeostasis and its breakdown in inflammatory bowel disease Nature , 2011; 474(7351):298-306
Michaud M, Martins I, Sukkurwala AQ, Adjemian S, Ma Y, Pellegatti P, Shen S, Kepp O, Scoazec M, Mignot G, Rello-Varona S, Tailler M, Menger L, Vacchelli E, Galluzzi L, Ghiringhelli F, di Virgilio F, Zitvogel L., Kroemer G. Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice Science, 2011; 334(6062): 1573-7
Ehlken H, Kondylis V, Heinrichsdorff J, Ochoa-Callejero L, Roskams T, Pasparakis M Hepatocyte IKK2 protects Mdr2-/- mice from chronic liver failure PLoS One, 2011; 6(10):e25942
Bonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva MA, Bloch W, Haase I, Pasparakis M The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation Immunity, 2011; 35(4):572-82
Welz PS, Wullaert A, Vlantis K, Kondylis V, Ferandez-Majada V, Ermolaeva M, Kirsch P, Sterner-Kock A, van Loo G, Pasparakis M FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation Nature, 2011 jul31; 477(7364):330-4
Vougioukalaki M, Kanellis DC, Gkouskou K, Eliopoulos AG Tpl2 kinase signal transduction in inflammation and cancer Cancer Lett , 2011 May 28;304(2):80-9.
Vlantis K, Wullaert A, Sasaki Y, Schmidt-Supprian M, Rajewsky K, Roskams T, Pasparakis M Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumours in mice J Clin Invest, 2011 121(7):2781-93
Bartek, J DNA damage response, genetic instability and cancer: from mechanistic insights to personalized treatment Mol Oncol, 2011; 5(4): 303-307
Eeles R, Knee G, Jhavar S, Mangion J, Ebbs S, Gui G, Thomas S, Coppen M, A'Hern R, Gray S, Cooper C, Bartek, J, Yarnold J Jamshidi M, Bartkova J, Greco D, Tommiska J, Fagerholm R, Aittomaki K, Mattson J, Villman K, Vrtel R, Lukas J, Heikkila P, Blomqvist C, Bartek, J, Nevanlinna H. NQo1 expression correlates inversely with NF-kB activation in human breast cancer Breast Cancer Res Treat, 2011
Manoukian S, PeisselB, Frigerio S, Lecis D, Bartkova J, Roversi G, Radice P, Bartek, J, Delia D. Two new CHEK2 germ-line variants detected in breast cancer/sarcoma families negative for BRCA1, BRCA2 and TP53 gene mutations Breast Cancer Res Treat, 2011; 130(1): 207-215
Sideridou M, Zakopoulou R, Evangelou K, Liontos M, Kotsinas A, Rampakis E, Gagos S, Kahata K, Grabusic K, Gkouskou K, Kolettas E, Volarevic S, Eliopoulos AG, Zannis-Hadjopoulos M, Moustakas A, Gorgoulis VG. Cdc6 acts as a "switch" at the E-cadherin locus linking transcriptional repression to activation of replication J Cell Biol, 2011; 195: 1123-40
Moudry P, Lukas C, Macurek L, Neumann JK, Heriche R, Pepperkok R, Ellenberg J, Hodney Z, Lukas J, Bartek, J Nucleosporin NUP153 guards genome integrity by promoting nuclear import of 53BP1 Cell Death Differ, 2011
Sgantzis N, Yiakouvaki A, Remboutsik E, Kontoyiannis DL. HuR controls lung branching morphogensis and mesenchymal FGF networks Dev Biol, 2011; 354:267-279
Maurer G, Tarkowski B, Baccarini M Raf kinases in cancer-roles and therapeutic opportunities Oncogene, 2011 30(32):3477-88
Yiakouvaki A, Dimitriou M, KarkasiliotisI, Eftychi C, Theocharis S, Kontoyiannis DL. Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis J Clin Invest, 2012; 122(1): 48-61
Perkins ND. The Diverse and Complex roles of NF-kB subunits in cancer Nature Rev Cancer, 2012 12(2):121-132
Golomb L, Bublick DR, Wilder S, Nevo R, Kiss V, Grabusic K, Volarevic S, Oren M. Importin & and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis Mol Cell, 2012; 45:222-32
Moschonas A, Ioannou M, Eliopoulos AG CD40 stimulates a "feed-forward" NF-κB-driven molecular pathway that regulates IFN-β expression in carcinoma cells J Immunol, 2012 Jun 1;188(11):5521-7
Rider P, Kaplanov I, Romzova M, Bernardis L, Braiman A, Voronov E, Apte RN The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells Front Immunol, 2012;3:290
Boulard O, Kirchberger S, Royston DJ, Maloy KJ, Powrie FM Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation J Exp Med, 2012 Jul 2;209(7):1309-24
Cotsiki M, Oehrl W, Samiotaki M, Theodosiou A, Panayotou G Phosphorylation of the M3/6 dual-specificity phosphatase enhances the activation of JNK by arsenite Cell Signal, 2012 Mar;24(3):664-76.
Karkali K, Panayotou G The Drosophila DUSP puckered is phosphorylated by JNK and p38 in response to arsenite-induced oxidative stress Biochem Biophys Res Commun, 2012 Feb 10;418(2):301-6.
Mann DA , Oakley F Serotonin paracrine signaling in tissue fibrosis Biochim Biophys Acta, 2012 Sep 29. pii: S0925-4439(12)00218-9.
Trempolec N, Dave-Coll N, Nebreda AR SnapShot: p38 MAPK Substrates Cell, 2013 Feb 14;152(4):924-924
Trempolec N, Dave-Coll N, Nebreda AR SnapShot: p38 MAPK Signaling. Cell, 2013 Jan 31;152(3):656-656
Perugorria MJ, Murphy LB, Fullard N, Chakraborty JB, Vyrla D, Wilson CL, Oakley F, Mann J, Mann DA Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells in mice. Hepatology, 2013 Mar;57(3):1238-49
Oehrl W, Cotsiki M, Panayotou G Differential regulation of M3/6 (DUSP8) signaling complexes in response to arsenite-induced oxidative stress Cell Signal, 2013 Feb;25(2):429-38
Gkirtzimanaki K, Gkouskou KK, Oleksiewicz U, Nikolaidis G, Vyrla D, Liontos M, Pelekanou V, Kanellis DC, Evangelou K, Stathopoulos EN, Field JK, Tsichlis PN, Gorgoulis V, Liloglou T, Eliopoulos AG. TPL2 kinase is a suppressor of lung carcinogenesis. Proc Natl Acad Sci U S A, 2013 Mar 26
Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E, Brenner DA, Apte RN , Jung S, Lapidot T . Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Nat Immunol, 2012 Nov;13(11):1072-82.
Rider P, Carmi Y, Guttman O, Braiman A, Cohen I, Voronov E, White MR, Dinarello CA, Apte RN. . IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation. J Immunol, 2011 Nov 1;187(9):4835-43.
Georgakopoulou EA, Tsimaratou K, Evangelou K, Fernandez-Marcos PJ, Zoumpourlis V, Trougakos IP, Kletsas D, Bartek J , Serrano M, Gorgoulis VG. Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues. Aging (Albany NY), 2013 Jan 5;5(1):37-50
Sohn JJ, Schetter AJ, Yfantis HG, Ridnour LA, Horikawa I, Khan MA, Robles AI, Hussain SP, Goto A, Bowman ED, Hofseth LJ, Bartkova J, Bartek J , Wogan GN, Wink DA, Harris CC. Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease. PLoS One, 2012;7(9)
Macurek L, Benada J, Müllers E, Halim VA, Krejčíková K, Burdová K, Pecháčková S, Hodný Z, Lindqvist A, Medema RH, Bartek J. Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis. Cell Cycle, 2013 Jan 15;12(2):251-62.
Dinant C, Bartek J , Bekker-Jensen S. Histone Displacement during Nucleotide Excision Repair. Int J Mol Sci, 2012 Oct 17;13(10):13322-37.
Oplustilova L, Wolanin K, Mistrik M, Korinkova G, Simkova D, Bouchal J, Lenobel R, Bartkova J, Lau A, O'Connor MJ, Lukas J, Bartek J. Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment. Cell Cycle, 2012 Oct 15;11(20):3837-50.
Schepeler T, Lamy P, Laurberg JR, Fristrup N, Reinert T, Bartkova J, Tropia L, Bartek J , Halazonetis TD, Pan CC, Borre M, Dyrskjøt L, Orntoft TF. A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response. Oncogene, 2012 Aug 27
Daugaard M, Baude A, Fugger K, Povlsen LK, Beck H, Sørensen CS, Petersen NH, Sorensen PH, Lukas C, Bartek J , Lukas J, Rohde M, Jäättelä M. LEDGF (p75) promotes DNA-end resection and homologous recombination. Nat Struct Mol Biol, 2012 Aug;19(8):803-10.
Falck J, Forment JV, Coates J, Mistrik M, Lukas J, Bartek J , Jackson SP. CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination. EMBO Rep, 2012 Jun;13(6):561-8.
Takacova S, Slany R, Bartkova J, Stranecky V, Dolezel P, Luzna P, Bartek J , Divoky V. DNA damage response and inflammatory signaling limit the MLL-ENL-induced leukemogenesis in vivo. Cancer Cell, 2012 Apr 17;21(4):517-31.
Moudry P, Lukas C, Macurek L, Hanzlikova H, Hodny Z, Lukas J, Bartek J. Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage. Cell Cycle, 2012 Apr 15;11(8):1573-82.
Bartek J Jr, Ng K, Bartek J, Fischer W, Carter B, Chen CC. Key concepts in glioblastoma therapy. J Neurol Neurosurg Psychiatry, 2012 Jul;83(7):753-60
Hamerlik P, Lathia JD, Rasmussen R, Wu Q, Bartkova J, Lee M, Moudry P, Bartek J Jr, Fischer W, Lukas J, Rich JN, Bartek J. Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. J Exp Med, 2012 Mar 12;209(3):507-20.
Sevcik J, Falk M, Macurek L, Kleiblova P, Lhota F, Hojny J, Stefancikova L, Janatova M, Bartek J, Stribrna J, Hodny Z, Jezkova L, Pohlreich P, Kleibl Z. Expression of human BRCA1Δ17-19 alternative splicing variant with a truncated BRCT domain in MCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damage response. Cell Signal, 2013 Feb 14;25(5):1186-1193.
Gudjonsson T, Altmeyer M, Savic V, Toledo L, Dinant C, Grøfte M, Bartkova J, Poulsen M, Oka Y, Bekker-Jensen S, Mailand N, Neumann B, Heriche JK, Shearer R, Saunders D, Bartek J, Lukas J, Lukas C. TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes. Cell, 2012 Aug 17;150(4):697-709.
Bartek J, Mistrik M, Bartkova J. Thresholds of replication stress signaling in cancer development and treatment. Nat Struct Mol Biol, 2012 Jan 5;19(1):5-7.
Hubackova S, Krejcikova K, Bartek J, Hodny Z. IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine 'Bystander senescence'. Aging (Albany NY), 2012 Dec;4(12):932-51.
Hubackova S, Krejcikova K,Bartek J, Hodny Z. Interleukin 6 signaling regulates promyelocytic leukemia protein gene expression in human normal and cancer cells. J Biol Chem, 2012  Aug 3;287(32):26702-14.
Strauss R, Hamerlik P, Lieber A, Bartek J. Regulation of stem cell plasticity: mechanisms and relevance to tissue biology and cancer. Mol Ther, 2012 May;20(5):887-97.
Koliaraki V, Roulis M, Kollias G. Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis. J Clin Invest, 2012 Nov 1;122(11):4231-42.
Bursać S, Brdovčak MC, Pfannkuchen M, Orsolić I, Golomb L, Zhu Y, Katz C, Daftuar L, Grabušić K, Vukelić I, Filić V, Oren M, Prives C, Volarevic S. Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Proc Natl Acad Sci U S A, 2012 Dec 11;109(50):20467-72.
Golomb L, Bublik DR, Wilder S, Nevo R, Kiss V, Grabusic K, Volarevic S, Oren M. Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis. Mol Cell, 2012 Jan 27;45(2):222-32.
Gkirtzimanaki K, Gkouskou KK, Oleksiewicz U, Nikolaidis G, Vyrla D, Liontos M, Pelekanou V, Kanellis DC, Evangelou K, Stathopoulos EN, Field JK, Tsichlis PN, Gorgoulis V, Liloglou T, Eliopoulos AG. . TPL2 kinase is a suppressor of lung carcinogenesis. PNAS , 2013 Apr 16;110(16):E1470-E1479. Epub 2013 Mar 26

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Designed by: George Savakis for Virtual Medical Lab (Faculty of Medicine - Univercity of Crete)