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FP7


The Programme


InflaCareINFLA-CARE (Inflammation and Cancer Research in Europe) is a four year collaborative research programme, funded by the European Commission,  which aims to develop new diagnostic tools and therapeutic strategies for malignancies associated with chronic inflammation.  This project will employ state-of-the-art pre-clinical models and cutting-edge technologies to characterize in detail the interactions between the tumour and its inflammatory microenvironment and to examine the role of inflammation-activated signal transduction in liver, lung and colorectal carcinogenesis.  The acquisition of this type of knowledge should make a positive impact on the development of targeted therapeutic strategies and the definition of new disease biomarkers leading to improved prophylactic care.

The 21 member consortium of INFLA-CARE comprises expert scientists and clinicians from Europe and Israel and is coordinated by the Institute of Molecular Biology & Biotechnology in Heraklion, Greece.


Project name: INFLA-CARE
Duration: 4 years, commencing 1 January 2009
Contract no.: 223151
Total cost: € 16,190,756
Commission funding: € 11,999,889



Research Highlights

The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression
Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease.
FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation
The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation
Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice
Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis
TPL2 kinase is a suppressor of lung carcinogenesis.


News News: The INFLA-CARE project is cited in "The Oncologist"
Posted by admin on Monday, July 29 @ 19:13:37 EEST (423 reads)

The INFLA-CARE project is cited by an EC Health Directory publication in "The Oncologist" as an example of how collaborative programmes in fundamental research can provide added value.

Emphasising the European Union's Commitment to Cancer Research: A Helicopter View of the Seventh Framework Programme for Research and Technological Development.
Read More... | News

News News: INFLA-CARE e-NewsLetter 3rd Issue;March 2013
Posted by admin on Thursday, April 18 @ 13:06:22 EEST (541 reads)

INFLA-CARE e-NewsLetter 3rd Issue;March 2013.
Read More... | News

News News: INFLA-CARE e-NewsLetter 2nd Issue;June 2012.
Posted by admin on Tuesday, April 02 @ 14:08:52 EEST (537 reads)

INFLA-CARE e-NewsLetter 2nd Issue;June 2012.
Read More... | News

News News: Poster
Posted by admin on Monday, April 18 @ 17:21:05 EEST (952 reads)

A poster for the high-impact journal Nature Reviews on Cancer on the theme of DNA damage signaling in early cancer and its relevance for therapy is published by INFLA-CARE scientist Jiri Bartek.
Read More... | News

News News: INFLA-CARE e-NewsLetter 1st Issue; February 2011.
Posted by admin on Sunday, March 13 @ 15:16:35 EET (959 reads)

INFLA-CARE e-NewsLetter 1st Issue; February 2011.

Read More... | News

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Designed by: George Savakis for Virtual Medical Lab (Faculty of Medicine - Univercity of Crete)